Protein Misfolding and ER Stress in Huntington's Disease
نویسندگان
چکیده
منابع مشابه
Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 2. Protein misfolding and ER stress.
The endoplasmic reticulum (ER) is a major site of protein synthesis, most strikingly in the specialized secretory cells of metazoans, which can produce their own weight in proteins daily. Cells possess a diverse machinery to ensure correct folding, assembly, and secretion of proteins from the ER. When this machinery is overwhelmed, the cell is said to experience ER stress, a result of the accum...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Biosciences
سال: 2019
ISSN: 2296-889X
DOI: 10.3389/fmolb.2019.00020